There is no problem to administer your site powered by Drupal because it is a very smart and friendly content management system. So your website can run without any big problems. But there is one thing you need to do and this thing could be very time expensive. You should periodically check if Drupal modules used on your site are up to date with bug fixes and improvements.
Checking all modules status one by one is very boring. Waiting for pages loading, reading about available updates... But there is a simple solution that helps you and can save your costly time. Try Update Status module for Drupal. If you have configured cron on your site properly, this module checks for available updates periodically every day and tells you if you need to do some action.
Update Status checks only for official releases with the name like 5.x-1.0. It doesn’t check for development version of modules with name like 5.x-1.x-dev. But this is not a problem. It is better to use only stable modules.